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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Mast/stem cell growth factor receptor Kit

SKU : BHE13805800

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0121d
Alternative Names	Proto-oncogene c-Kit ; Tyrosine-protein kinase Kit ; CD117
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Specificity	Natural and recombinant Dog Mast/stem cell growth factor receptor Kit
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	0.312-20ng/mL
Entryname	KIT_CANFA
Method Type	Sandwich
Platform	PF07679
Protein Name	Mast/stem cell growth factor receptor Kit
Sensitivity	0.15ng/mL
Sequence	50: MRGARGAWDF ; LCVLLLLLLL ; GVQTGSSQPS ; VSPGEPSLPS ; IHPAKSELIV ; 100: SVGDELRLSC ; TDPGFVKWTF ; ETLGQLNENT ; HNEWITEKAE ; AGHTGNYTCT ; 150: NRDGLSRSIY ; VFVRDPAKLF ; LVDLPLYGKE ; GNDTLVRCPL ; TDPEVTNYSL ; 200: RGCEGKPLPK ; DLTFVADPKA ; GITIRNVKRE ; YHRLCLHCSA ; DQKGRTVLSK ; 250: KFTLKVRAAI ; RAVPVVSVSK ; TSSLLKEGEA ; FSVMCFIKDV ; SSFVDSMWIK ; 300: ENSQQTNAQT ; QSNSWHHGDF ; NFERQEKLII ; SSARVNDSGV ; FMCYANNTFG ; 350: SANVTTTLEV ; VDKGFINIFP ; MMSTTIFVND ; GENVDLIVEY ; EAYPKPEHQQ ; 400: WIYMNRTFTD ; KWEDYPKSDN ; ESNIRYVSEL ; HLTRLKGNEG ; GTYTFQVSNS ; 450: DVNSSVTFNV ; YVNTKPEILT ; HESLTNGMLQ ; CVVAGFPEPA ; VDWYFCPGAE ; 500: QRCSVPIGPM ; DVQMQNSSLS ; PSGKLVVQSS ; IDYSAFKHNG ; TVECRAYNNV ; 550: GRSSAFFNFA ; FKGNSKEQIH ; PHTLFTPLLI ; GFVIAAGMMC ; IIVMILTYKY ; 600: LQKPMYEVQW ; KVVEEINGNN ; YVYIDPTQLP ; YDHKWEFPRN ; RLSFGKTLGA ; 650: GAFGKVVEAT ; AYGLIKSDAA ; MTVAVKMLKP ; SAHLTEREAL ; MSELKVLSYL ; 700: GNHMNIVNLL ; GACTVGGPTL ; VITEYCCYGD ; LLNFLRRKRD ; SFICSKQEDH ; 750: GEVALYKNLL ; HSKESSCSDS ; TNEYMDMKPG ; VSYVVPTKAD ; KRRSARIGSY ; 800: IERDVTPAIM ; EDDELALDLE ; DLLSFSYQVA ; KGMAFLASKN ; CIHRDLAARN ; 850: ILLTHGRITK ; ICDFGLARDI ; KNDSNYVVKG ; NARLPVKWMA ; PESIFNCVYT ; 900: FESDVWSYGI ; FLWELFSLGS ; SPYPGMPVDS ; KFYKMIKEGF ; RMLSPEHAPA ; 950: EMYDIMKTCW ; DADPLKRPTF ; KQIVQLIEKQ ; ISDSTNHIYS ; NLANCSPNPE ; 979: RPVVDHSVRI ; NSVGSSASST ; QPLLVHEDV
Sequence Length	979
String	O97799
Sub Unit	Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1.

Uniprot	O97799
Gene Name	KIT
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:403811
Unigene	Cfa.184

Reference	1. "Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms." Ma Y., Longley B.J., Wang X., Blount J.L., Langley K., Caughey G.H. J. Invest. Dermatol.112:165-170(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) 2. Zemke D., Yuzbasiyan-Gurkan V. Submitted (2001-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 3. "Characterization of an isoform and RH mapping of canine c-kit." Tsai K.L., Guyon R., Murphy K.E. Submitted (2003-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805800	E0121d	96T	$900		Add to Cart

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