Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Specificity
Natural and recombinant Dog cGMP-specific 3',5'-cyclic phosphodiesterase
Subcellular Location
Cytoplasm Cytoplasm cytosol PDE5A1 and PDE5A2 are located mostly to soluble cellular fractions and some to particulate cellular fractions.
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