Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells.
Specificity
Natural and recombinant Dog Calreticulin
Subcellular Location
Endoplasmic reticulum lumen
Entryname
CALR_CANFA
Method Type
Sandwich
Protein Name
Calreticulin
Sequence
24:
EPAIYFKEQF ; LDGXGFTDXR ; IKEK
Sequence Length
24
Sub Unit
Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with GABARAP, NR3C1, PDIA3/ERp57 and TRIM21.
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