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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Serine/threonine-protein kinase 4

SKU : BHE13810775

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13100c
Alternative Names	RCJMB04_17i1
Categories	Elisa
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
Specificity	Natural and recombinant Chicken Serine/threonine-protein kinase 4
Subcellular Location	Cytoplasm Nucleus The caspase-cleaved form cycles between nucleus and cytoplasm.
Entryname	STK4_CHICK
Platform	PF11629
Protein Name	Serine/threonine-protein kinase 4
Sequence	50: METVQLRNPR ; RQLKKLDEDS ; LTKQPEEVFD ; VLEKLGEGSY ; GSVFKAIHKE ; 100: TGQVVAIKQV ; PVESDLQEII ; KEISIMQQCD ; SPHVVKYYGS ; YFKNTDLWIV ; 150: MEYCGAGSVS ; DIIRLRNKTL ; TEEEIATIVQ ; STLKGLEYLH ; FMRKIHRDIK ; 200: AGNILLNTEG ; HAKLADFGVA ; GQLTDTMAKR ; NTVIGTPFWM ; APGVIQEIGY ; 250: NCVADIWSLG ; ITAIEMAEGK ; PPYADIHPMR ; AIFMIPTNPP ; PTFRKPELWS ; 300: DAFTDFVKQC ; LVKSPEQRAT ; AIQLLQHPFV ; KSAKGASILR ; DLINEAMDIK ; 350: LKRQEAQQRE ; LDQEDEENSE ; EDETDSGTMV ; RASGDETGTI ; RVVNTMSDGA ; 400: NTMIEHDGTL ; ESQLGTMVIN ; TEDEEEEGTM ; KRRDETMQPA ; RPSFLEYFEQ ; 450: KAKENQVNSF ; GKNVSGQTKN ; SSDWKVPQDG ; DYEFLKTWSV ; DELQRRLSAL ; 486: DPMMEQEIEE ; IRQKYQSKRQ ; PILDAIEAKK ; RRQQNF
Sequence Length	486
Sub Unit	Homodimer; mediated via the coiled-coil region.

Uniprot	Q5ZJK4
Gene Name	STK4
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:419187
Unigene	Gga.15820

Reference	1. "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol.6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: CB. tissue: Bursa of Fabricius.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810775	E13100c	96T	$900		Add to Cart

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