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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Proto-oncogene c-Rel

SKU : BHE13808904

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15270c
Alternative Names	p68
Categories	Elisa
Function	Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Specificity	Natural and recombinant Chicken Proto-oncogene c-Rel
Subcellular Location	Nucleus
Detection Range	78-5000pg/mL
Entryname	REL_CHICK
Method Type	Sandwich
Platform	PF00554
Protein Name	Proto-oncogene c-Rel
Sensitivity	34pg/mL
Sequence	50: MAGISEPYIE ; IFEQPRQRGM ; RFRYKCEGRS ; AGSIPGEHST ; DNNKTFPSIQ ; 100: ILNYFGKVKI ; RTTLVTKNEP ; YKPHPHDLVG ; KDCRDGYYEA ; EFGPERRVLS ; 150: FQNLGIQCVK ; KKDLKESISL ; RISKKINPFN ; VPEEQLHNID ; EYDLNVVRLC ; 200: FQAFLPDEHG ; NYTLALPPLI ; SNPIYDNRAP ; NTAELRICRV ; NKNCGSVKGG ; 250: DEIFILCDKV ; QKDDIEVRFV ; LDNWEAKGSF ; SQADVHRQVA ; IVFRTPPFLR ; 300: DITEPITVKM ; QLRRPSDQEV ; SEPMDFRYLP ; DEKDPYGNKA ; KRQRSTLAWQ ; 350: KLIQDCGSAV ; TERPKAAPIP ; TVNPEGKLIK ; KEPNMFSPTL ; MLPGLGTLTS ; 400: SSQMYPPCSQ ; MPHQPAQLGP ; GKQDTLPSCW ; QQLFSSSPSA ; SSLLSMHPHN ; 450: SFTAEVPQPG ; AQGSSSLPAF ; HDNPLNWPDE ; KDSSFYRNFG ; STNGMGAAMV ; 500: SAADMQSASS ; NSIVHATHQA ; SATAASIVNM ; ETNDMNCTSL ; NFEKYTQVLN ; 550: VSNHRQQLHQ ; APAACPPVAA ; PGSTPFSSQP ; NLADTAVYNS ; FLDQEVISDS ; 598: RLSTNPLQNH ; QNSLTLTDNQ ; FYDTDGVHTD ; ELYQSFQLDT ; NILQSYNH
Sequence Length	598
String	P16236
Sub Unit	Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex. Component of the NF-KAPPA-B p65-c-Rel complex.

Uniprot	P16236
Gene Name	REL
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:396500
Unigene	Gga.10724

Reference	1. "Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts." Capobianco A.J., Simmons D.L., Gilmore T.D. Oncogene5:257-265(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Fibroblast. 2. "Characterization of a novel promoter insertion in the c-rel locus." Kabrun N., Bumstead N., Hayman M.J., Enrietto P.J. Mol. Cell. Biol.10:4788-4794(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-7 3. "Transactivation of gene expression by nuclear and cytoplasmic rel proteins." Hannink M., Temin H.M. Mol. Cell. Biol.9:4323-4336(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-598 4. "Isolation of the chicken NF-kappa B p65 subunit-encoding cDNA and characterization of its products." Ikeda T., Honjo K., Hirota Y., Onodera T. Gene133:237-242(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX 5. "Proteomic analysis of the Gallus gallus embryo at stage-29 of development." Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J., Schneider J., Palomar M.A., Linares R. Proteomics5:4946-4957(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;MASS SPECTROMETRY tissue: Embryo. 6. "X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2." Huang D.B., Chen Y.Q., Ruetsche M., Phelps C.B., Ghosh G. Structure9:669-678(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 7-281 IN COMPLEX WITH IL2 DNA

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BHE13808904	E15270c	96T	$900		Add to Cart

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