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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Presenilin-1

SKU : BHE13808966

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15382c
Categories	Elisa
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Specificity	Natural and recombinant Chicken Presenilin-1
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cell surface
Entryname	PSN1_CHICK
Platform	PF01080
Protein Name	Presenilin-1
Sequence	50: MTELSAHLPQ ; FQHGQMTENF ; PDNHLSNTND ; NSERRRHDNS ; ERRRNDNPGS ; 100: ETNGQPQNNI ; QQVVDQDEEE ; DEELTLKYGA ; KHVIMLFVPV ; TLCMVVVVAT ; 150: IKSVSFYTRK ; DGQLIYTPFT ; EETDTIGQRA ; LNSILNAAIM ; ISVIIVMTIL ; 200: LVVLYKYRCY ; KVIHGWLIIS ; SLLLLFFFSF ; IYLGEVFKTY ; NVAMDYITVA ; 250: LIIWNFGVVG ; MICIHWKGPL ; RLQQAYLIMI ; SALMALVFIK ; YLPEWTAWLI ; 300: LAVISVYDLV ; AVLCPKGPLR ; MLVETAQERN ; ETLFPALIYS ; STMVWLVNMA ; 350: EEDPEGQRKA ; SKNSTYDKQA ; PANQSQNEDA ; EADDGGFSQE ; WQQQRDNRIG ; 400: PIESTPESRA ; AVQALPSNSQ ; TSEDPEERGV ; KLGLGDFIFY ; SVLVGKASAT ; 450: ASGDWNTTLA ; CFVAILIGLC ; LTLLLLAIFK ; KALPALPISI ; TFGLVFYFAT ; 468: DNLVQPFMDQ ; LAFHQFYI
Sequence Length	468
String	Q4JIM4
Sub Unit	Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment.

Uniprot	Q4JIM4
Gene Name	PSEN1
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:373977
Unigene	Gga.3864

Reference	1. "Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules." Mirinics Z.K., Calafat J., Udby L., Lovelock J., Kjeldsen L., Rothermund K., Sisodia S.S., Borregaard N., Corey S.J. Blood Cells Mol. Dis.28:28-38(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: B-cell. 2. "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1." Rubio M.E., Curcio C., Chauvet N., Bruses J.L. Mol. Cell. Neurosci.30:118-130(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH CDH2 tissue: Ciliary ganglion.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808966	E15382c	96T	$900		Add to Cart

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