Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators.
Specificity
Natural and recombinant Chicken Hypoxia-inducible factor 1-alpha
Subcellular Location
Cytoplasm Nucleus Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
"Molecular cloning and expression of an avian cDNA for hypoxia-inducible factor-1 alpha in embryonic ventricular myocytes." Takahashi T. Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
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