This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia.
Specificity
Natural and recombinant Chicken Glutamine synthetase
Subcellular Location
Cytoplasm Mitochondrion In the liver found in mitochondria, in brain and retina in the cytoplasm. In retinal cells found in the outer part of the inner nuclear layer and in the bacillary layer of the photoreceptor, and is probably associated with the cell membrane.
"Evolution of mitochondrial targeting mechanisms: tissue-specific subcellular localization of glutamine synthetase." Matthews G.D., Gur N., Pines O., Vardimon L. Submitted (2008-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55
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Reviews of ELISA Kit for Chicken Glutamine synthetase