ELISA Kit for Chicken Frizzled-8

Mfr.No.	E1714c
Alternative Names	FZ8
Categories	Elisa
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Specificity	Natural and recombinant Chicken Frizzled-8
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Entryname	FZD8_CHICK
Platform	PF01534
Protein Name	Frizzled-8
Sequence	50: AGAAELQPEL ; AVAEHVRYES ; TGPALCTVVF ; LLVYFFGMAS ; SIWWVILSLT ; 100: WFLAAGMKWG ; NEAIAGYAQY ; FHLAAWLLPS ; VKSIAVLALS ; SVDGDPVAGI ; 150: CYVGNQSLEN ; LRGFVLAPLV ; VYLFTGSLFL ; LAGFVSLFRI ; RSVIKQGGTK ; 200: TDKLEKLMIR ; IGIFTVLYTV ; PATIVIACYI ; YEQHNREAWE ; QAQNCSCPGD ; 217: PHRPKPDYAV ; FMLKYFM
Sequence Length	217
String	Q9IA03

Reference	1. "Characterization of avian frizzled genes in cranial placode development." Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S. Mech. Dev.93:195-200(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-157 tissue: Embryo. 2. "Differential expression of the frizzled family involved in Wnt signaling during chick limb development." Nohno T., Kawakami Y., Wada N., Komaguchi C., Nishimatsu S. Cell. Mol. Biol.45:653-659(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-217 tissue: Limb bud.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805112	E1714c	96T	$900		Add to Cart