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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Ephrin type-A receptor 4

SKU : BHE13804498

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0303c
Alternative Names	EPH-like kinase 8 ; EK8 ; CEK8
Categories	Elisa
Function	Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections.
Specificity	Natural and recombinant Chicken Ephrin type-A receptor 4
Subcellular Location	Cell membrane Single-pass type I membrane protein Early endosome Clustered upon activation and targeted to early endosome.
Entryname	EPHA4_CHICK
Platform	PF14575
Protein Name	Ephrin type-A receptor 4
Sequence	50: MAGVPVGALL ; PLLVGVCGAV ; TGSRVYPANE ; VTLLDSRSVQ ; GELGWIASPL ; 100: EGGWEEVSIM ; DEKNTPIRTY ; QVCNVMEPSQ ; NNWLRTDWIP ; REGAQRVYIE ; 150: IKFTLRDCNS ; LPGVMGTCKE ; TFNLYYYESN ; NDKERFIRES ; QFAKIDTIAA ; 200: DESFTQVDIG ; DRIMKLNTEV ; RDVGPLSKKG ; FYLAFQDVGA ; CIALVSVRVF ; 250: YKKCPLTVRN ; LAQFPDTITG ; ADTSSLVEVR ; GSCVNNSEEK ; DVPKMYCGAD ; 300: GEWLVPIGNC ; LCNAGYEERN ; GECQACKIGY ; YKALSTDVAC ; AKCPPHSYSI ; 350: WEGSTSCTCD ; RGFFRAENDA ; ASMPCTRPPS ; APQNLISNVN ; ETSVNLEWSA ; 400: PQNKGGRDDI ; SYNVVCKRCG ; AGEPSHCRSC ; GSGVHFSPQQ ; NGLKTTKVSI ; 450: TDLLAHTNYT ; FEVWAVNGVS ; KHNPSQDQAV ; SVTVTTNQAA ; PSPIALIQAK ; 500: EITRHSVALA ; WLEPDRPNGV ; ILEYEVKYYE ; KDQNERSYRI ; VKTASRNTDI ; 550: KGLNPLTSYV ; FHVRARTAAG ; YGDFSGPFEF ; TTNTVPSPII ; GDGTNPTVLL ; 600: VSVAGSVVLV ; VILIAAFVIS ; RRRSKYSKAK ; QEADEEKHLN ; QGVRTYVDPF ; 650: TYEDPNQAVR ; EFAKEIDASC ; IKIEKVIGVG ; EFGEVCSGRL ; KVPGKREICV ; 700: AIKTLKAGYT ; DKQRRDFLSE ; ASIMGQFDHP ; NIIHLEGVVT ; KCKPVMIITE ; 750: YMENGSLDAF ; LRKNDGRFTV ; IQLVGMLRGI ; GSGMKYLSDM ; SYVHRDLAAR ; 800: NILVNSNLVC ; KVSDFGMSRV ; LEDDPEAAYT ; TRGGKIPIRW ; TAPEAIAYRK ; 850: FTSASDVWSY ; GIVMWEVMSY ; GERPYWDMSN ; QDVIKAIEEG ; YRLPPPMDCP ; 900: IALHQLMLDC ; WQKERSDRPK ; FGQIVNMLDK ; LIRNPNSLKR ; TGSESSRPST ; 950: ALLDPSSPEF ; SAVVSVSDWL ; QAIKMERYKD ; NFTAAGYTTL ; EAVVHMNQDD ; 986: LARIGITAIT ; HQNKILSSVQ ; AMRSQMQQMH ; GRMVPV
Sequence Length	986
String	Q07496
Sub Unit	Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602 (By similarity). Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.

Uniprot	Q07496
Gene Name	EPHA4
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:395559
Unigene	Gga.304

Reference	1. "The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development." Ohta K., Nakamura M., Hirokawa K., Tanaka S., Iwama A., Suda T., Ando M., Tanaka H. Mech. Dev.54:59-69(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Spinal cord. 2. "Five novel avian Eph-related tyrosine kinases are differentially expressed." Sajjadi F.G., Pasquale E.B. Oncogene8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-986 tissue: Embryo. 3. "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases." Richter M., Murai K.K., Bourgin C., Pak D.T., Pasquale E.B. J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIPA1L1

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804498	E0303c	96T	$900		Add to Cart

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