Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Specificity
Natural and recombinant Bovine Transcription factor AP-1
Heterodimer with either FOS or BATF3 or ATF7 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (By similarity). Interacts with HIVEP3. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187 and HIPK3.
"Stimulation of c-fos and c-jun mRNA in bovine luteal cells." Davis J.S., Fong H.W., Westfall S.W. Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-110