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ELISA Kit for Bovine Switch-associated protein 70

SKU : BHE13810414

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3416b
Categories	Elisa
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Specificity	Natural and recombinant Bovine Switch-associated protein 70
Subcellular Location	Cytoplasm Cell membrane Nucleus Cell projection lamellipodium In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Entryname	SWP70_BOVIN
Platform	PF00169
Protein Name	Switch-associated protein 70
Sequence	50: MGSLKDELLK ; GIWHAFTALD ; LDHSGKVSKS ; QLKVLSHNLC ; TVLKVPHDPV ; 100: ALEEHFRDDD ; EGPVSNQGYM ; PYLNKFILEK ; VQDNFDKIEF ; NRMCWTLCVK ; 150: KNLTKNPLFI ; TEEDAFKIWV ; IFNFLSEDKY ; PLIIVPEEIE ; YLLKKLTEAM ; 200: GVSWQQEQFE ; NYKINFDDSK ; DGLSAWELIE ; LVGNGQFSKG ; MDRQTVSMAI ; 250: NEVFNELILD ; VLKQGYMIKK ; GHRRKNWTER ; WFVLKPHIIS ; YYVSEDLKDK ; 300: KGDILLDENC ; CVESLPDKDG ; KKCLFLIKCF ; DKTFEISASD ; KKKKQEWIQA ; 350: IHSTIHLLKL ; GSPPPHKEAR ; QRRKELRKKL ; LAEQEELERQ ; MKELQIANEN ; 400: KQQELEAVRK ; KLEEAASRAA ; EEEKKRLQTQ ; VELQARFSTE ; LEREKLIRQQ ; 450: MEEQVAQKSS ; ELEQYLQRVR ; ELEDMYLKLQ ; EALEDERQAR ; QDEETVRKLQ ; 500: ARLLEEESSK ; RAELEKWHLE ; QQQAIQTTEA ; EKQELENQRV ; IKEQALQEAL ; 550: EQLQQLELER ; KQALEQYEGV ; KKKLEMAAKM ; TKSWKDKVAH ; HEGLIRLIEP ; 585: GSKNAHLITN ; WGPAAFTQAE ; LEERQKSWKE ; KKTTE
Sequence Length	585
Sub Unit	The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.

Uniprot	P0C1G6
Gene Name	SWAP70
Immunogen Species	Bos Taurus (Cattle)
Unigene	Bt.15774

Reference	1. "Bovine genome sequencing program: full-length cDNA sequencing." Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A., Holt R., Jones S.J., Marra M.A.more... Submitted (2005-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 2. "SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling." Shinohara M., Terada Y., Iwamatsu A., Shinohara A., Mochizuki N., Higuchi M., Gotoh Y., Ihara S., Nagata S., Itoh H., Fukui Y., Jessberger R. Nature416:759-763(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-40; 448-457; 466-474; 482-490 AND 492-507;MUTAGENESIS OF ARG-230 AND LYS-291;DOMAIN;FUNCTION;SUBCELLULAR LOCATION tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810414	E3416b	96T	$900		Add to Cart

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