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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Spastin

SKU : BHE13810613

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15329b
Alternative Names	SPG4
Categories	Elisa
Function	ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
Specificity	Natural and recombinant Bovine Spastin
Subcellular Location	Membrane Single-pass membrane protein Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton Cytoplasm perinuclear region Endoplasmic reticulum Endosome Nucleus Cytoplasm cytoskeleton spindle Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons.
Entryname	SPAST_BOVIN
Platform	PF00004
Protein Name	Spastin
Sequence	50: MNSPGGRGKK ; KGSGGPSSPV ; PPRPPPPCQA ; RSRPAPKPAP ; PPQSPHKRNL ; 100: YYFSYPLFLG ; FALLRLVAFH ; LGLLFVWLCQ ; RFSRALMAAK ; RSSGAAPASA ; 150: SPPAPVPGGE ; AERVRAFHKQ ; AFEYISVALR ; IDEDEKVGQK ; DQAVEWYKKG ; 200: IEELEKGIAV ; VVTGQGEQCE ; RARRLQAKMM ; TNLVMAKDRL ; QLLEKLQPSL ; 250: QFSKSQTDVY ; NDSTNLTCRN ; GHLQSESGAV ; PKRKDPLTHA ; SNSLPRSKTV ; 300: MKTGPTGLSG ; HHRAPSCSGL ; SMVSGVRQGP ; GSAAATHKST ; PKTNRTNKPS ; 350: TPTTAARKKK ; DLKNFRNVDS ; NLANLIMNEI ; VDNGTAVKFD ; DIAGQELAKQ ; 400: ALQEIVILPS ; LRPELFTGLR ; APARGLLLFG ; PPGNGKTMLA ; KAVAAESNAT ; 450: FFNISAASLT ; SKYVGEGEKL ; VRALFAVARE ; LQPSIIFIDE ; VDSLLCERRE ; 500: GEHDASRRLK ; TEFLIEFDGV ; QSAGDDRVLV ; MGATNRPQEL ; DEAVLRRFTK ; 550: RVYVSLPNEE ; TRLLLLKNLL ; CKQGSPLTQK ; ELAQLARMTN ; GYSGSDLTAL ; 600: AKDAALGPIR ; ELKPEQVKNM ; SASEMRNIRL ; SDFTESLKKI ; KRSVSPQTLE ; 614: AYIRWNKDFG ; DTTV
Sequence Length	614
String	A2VDN5
Sub Unit	Homohexamer. Binding to ATP stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer may adopt a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with ATL1, RTN1, SSNA1 and ZFYVE27.

Uniprot	A2VDN5
Gene Name	SPAST
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:521442
Unigene	Bt.46123

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2007-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Brain cortex.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810613	E15329b	96T	$900		Add to Cart

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