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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Secretory phospholipase A2 receptor

SKU : BHE13809433

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2020b
Alternative Names	180 kDa secretory phospholipase A2 receptor ; M-type receptor
Categories	Elisa
Function	Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.
Specificity	Natural and recombinant Bovine Secretory phospholipase A2 receptor
Subcellular Location	Soluble secretory phospholipase A2 receptor Secreted
Entryname	PLA2R_BOVIN
Platform	PF00040
Protein Name	Secretory phospholipase A2 receptor
Sequence	50: MPLLSLSLLL ; LLLQVPAGSA ; ETAAWAVTPE ; RLREWQDKGI ; FIIQSENLEK ; 100: CIQASKSTLT ; LENCKPPNKY ; MLWKWVSNHR ; LFNIGGSGCL ; GLNVSSPEQP ; 150: LSIYECDSTH ; VSLKWHCNKK ; TITGPLQYLV ; QVKQDNTLVA ; SRKYLHKWVS ; 200: YMSGGGGICD ; YLHKDLYTIK ; GNAHGTPCMF ; PFQYNQQWHH ; ECTREGREDN ; 250: LLWCATTSRY ; ERDEKWGFCP ; DPTSTEVGCD ; AVWEKDLHSR ; ICYQFNLLSS ; 300: LSWSEAHSSC ; QMQGAALLSI ; ADETEENFVR ; KHLGSEAVEV ; WMGLNQLDED ; 350: AGWQWSDRTP ; LNYLNWKPEI ; NFEPFVEYHC ; GTFNAFMPKA ; WKSRDCESTL ; 400: PYVCKKYLNP ; TDHGVVEKDA ; WKYYATHCEP ; GWNPHNRNCY ; KLQKEKKTWN ; 450: EALQSCQSNN ; SVLTDITSLA ; EVEFLVTLLG ; DENASETWIG ; LSSHKIPVSF ; 500: EWSNGSSVTF ; TNWHTLEPHI ; FPNRSQLCVS ; AEQSEGHWKV ; KNCEETLFYL ; 550: CKKTGLVLSD ; TESGCQKGWE ; RHGKFCYKID ; TVLRSFDHAS ; SGYYCPPALI ; 600: TITSRFEQAF ; ITSLISSVVK ; TKDTYFWIAL ; QDQNNTGEYT ; WKTAGQQLEP ; 650: VKYTHWNTRQ ; PRYSGGCVVM ; RGRSHPGRWE ; VRDCRHFKAM ; SLCKQPVENR ; 700: EKTKQEEGWP ; FHPCYLDWES ; EPGLASCFKV ; FHSEKVLMKR ; TWRQAEEFCE ; 750: EFGAHLASFA ; HIEEENFVNE ; LLHSKFNRTE ; ERQFWIGFNK ; RNPLNAGSWE ; 800: WSDGTPVVSS ; FLDNSYFGED ; ARNCAVYKAN ; KTLLPSYCGS ; KREWICKIPR ; 850: DVRPKVPPWY ; QYDAPWLFYQ ; DAEYLFHISA ; SEWSSFEFVC ; GWLRSDILTI ; 900: HSAHEQEFIH ; SKIRALSKYG ; VNWWIGLREE ; RASDEFRWRD ; GSPVIYQNWD ; 950: KGKERSMGLN ; ESQRCGFISS ; ITGLWASEEC ; SISMPSICKR ; KKVWVIEKKK ; 1000: DIPKQHGTCP ; KGWLYFDYKC ; LLLKIPEGPS ; DWKNWTSAQD ; FCVEEGGTLV ; 1050: AIENEVEQAF ; ITMNLFGHTT ; NVWIGLQDDD ; YEKWLNGRPV ; SYSNWSPFDT ; 1100: KNIPNHNTTE ; VQKRIPLCGL ; LSNNPNFHFT ; GKWYFEDCRE ; GYGFVCEKMQ ; 1150: DASGHSINTS ; DMYPIPNTLE ; YGNRTYKIIN ; ANMTWYTALK ; TCLMHGAELA ; 1200: SITDQYHQSF ; LTVILNRVGY ; AHWIGLFTED ; NGLSFDWSDG ; TKSSFTFWKD ; 1250: DESSFLGDCV ; FADTSGRWSS ; TACESYLQGA ; ICQVPTETRL ; SGRLELCSET ; 1300: SIPWIKFKSN ; CYSFSTVLES ; TSFEAAHEFC ; KKKGSNLLTI ; KDEAENSFLL ; 1350: EELLAFRSSV ; QMIWLNAQFD ; GDNETIKWFD ; GTPTDQSNWG ; IRKPEVYHFK ; 1400: PHLCVALRIP ; EGVWQLSSCQ ; DKKGFICKME ; ADIHTVKKHP ; GKGPSHSVIP ; 1450: LTVALTLLVI ; LAISTLSFCM ; YKHSHIIFGR ; LAQFRNPYYP ; SANFSTVHLE ; 1463: ENILISDLEK ; NDQ
Sequence Length	1463

Uniprot	P49259
Gene Name	PLA2R1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:317777
Unigene	Bt.97059

Reference	1. "Molecular cloning of pancreatic group I phospholipase A2 receptor." Ishizaki J., Hanasaki K., Higashino K., Kishino J., Kikuchi N., Ohara O., Arita H. J. Biol. Chem.269:5897-5904(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF N-TERMINUS 2. "Glycosylation-dependent binding of pancreatic type I phospholipase A2 to its specific receptor." Fujita H., Kawamoto K., Hanasaki K., Arita H. Biochem. Biophys. Res. Commun.209:293-299(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809433	E2020b	96T	$900		Add to Cart

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