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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Poly [ADP-ribose] polymerase 1

SKU : BHE13808639

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0947b
Antigen	PARP1
Alternative Names	ADP-ribosyltransferase diphtheria toxin-like 1 ; ARTD1 ; NAD(+) ADP-ribosyltransferase 1 ; ADPRT 1 ; Poly[ADP-ribose] synthase 1 ; ADPRT
Categories	Elisa
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Specificity	Natural and recombinant Bovine Poly [ADP-ribose] polymerase 1
Subcellular Location	Nucleus
Entryname	PARP1_BOVIN
Platform	PF00533
Protein Name	Poly [ADP-ribose] polymerase 1
Sequence	50: MAESSDKLYR ; VEYAKSGRAS ; CKKCKESIPK ; DSIRMAFMVE ; SPMFDGKIPH ; 100: WYHLSCFWKV ; GFSIWHPDVE ; VEGFSELRWD ; DQQTIKKMAE ; TGGRTDVSGK ; 150: GQDGVGSKTE ; KTLIDFGAGY ; AKSNRSTCKS ; CMEKIDKGQV ; RLSKKVVYPD ; 200: KPQLGMVDCW ; YHPKCFVQKR ; EELGFRPEFS ; ATHLMGFSVL ; TAEDQETLKK ; 250: QLPAIKGERK ; RKGDEVDGID ; EVTKKKSKKE ; KDKEIKLEKA ; LKAQNDLIWN ; 300: VKDELKKACS ; TNDLKELLIF ; NKQEVPSGES ; AILDRVADGM ; VFGALLPCEE ; 350: CSGQLVFKGD ; AYYCTGDVTA ; WTKCMVKTQT ; PNRKEWVTPK ; EFREISYFKK ; 400: LKIKKQDRIF ; PPESSTPVGA ; AAPPSAASAP ; AAVHSGPPDK ; PLSNMKILTL ; 450: GKLSQNKDEV ; KATIEKLGGK ; LTGTANKASL ; CISTKKEVDK ; LNKKMEEVKE ; 500: ANIRVVSEDF ; LQDISASTKS ; LQELLSTHLL ; SPWGAEVKVE ; PVEAVGPKGK ; 550: SGAAPSKKSK ; GPVKEEGTNK ; SEKRMKLTLK ; GGAAVDPDSG ; LEHNAHVLEK ; 600: GGKVFSATLG ; LVDIVKGTNS ; YYKLQLLEDD ; KESRYWIFRS ; WGRVGTVIGS ; 650: NKLEQMPSKE ; DAIEHFMKLY ; EEKTGNAWHS ; KNFTKHPKKF ; YPLEIDYGQD ; 700: EEAVKKLTVN ; PGTKSKLPKP ; VQNLIKMIFD ; VESMKKAMVE ; YEIDLQKMPL ; 750: GKLSKRQIQA ; AYSILSEVQQ ; ALSQGSSDSH ; ILDLSNRFYT ; LIPHDFGMKK ; 800: PPLLNNANSV ; QAKVEMLDNL ; LDIEVAYSLL ; RGGSDDSSKD ; PIDVNYEKLK ; 850: TDIKVVDKDS ; EEAEIIRKYV ; KNTHATTHNA ; YDLEVVDIFK ; IEREGESQRY ; 900: KPFKQLHNRR ; LLWHGSRTTN ; FAGILSQGLR ; IAPPEAPVTG ; YMFGKGIYFA ; 950: DMVSKSANYC ; HTSQGDPIGL ; ILLGEAALGN ; MYELKHARHI ; SKLPKGKHSV ; 1000: KGLGKTTPDP ; SASITVDGVE ; VPLGTGISSG ; VNDTCLLYNE ; YIVYDIAQVH ; 1016: LKYLLKLKFN ; FKTSLW
Sequence Length	1016
String	P18493
Sub Unit	Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3 and APTX. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 and SRY. Interacts with TIAM2 and ZNF423, Interacts (when poly-ADP-ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Uniprot	P18493
Gene Name	PARP1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:286764
Unigene	Bt.4803

Reference	1. "Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions." Saito I., Hatakeyama K., Kido T., Ohkubo H., Nakanishi S., Ueda K. Gene90:249-254(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells." Taniguchi T., Yamauchi K., Yamamoto T., Toyoshima K., Harada N., Tanaka H., Takahashi S., Yamamoto H., Fujimoto S. Eur. J. Biochem.171:571-575(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 648-715 AND 839-904

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BHE13808639	E0947b	96T	$900		Add to Cart

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