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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Neuronal calcium sensor 1

SKU : BHE13808172

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13770b
Alternative Names	Frequenin homolog ; FREQ
Categories	Elisa
Function	Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
Specificity	Natural and recombinant Bovine Neuronal calcium sensor 1
Subcellular Location	Golgi apparatus Golgi stack membrane Peripheral membrane protein Cell junction synapse postsynaptic cell membrane postsynaptic density Cytoplasm perinuclear region Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
Entryname	NCS1_BOVIN
Platform	PF00036
Protein Name	Neuronal calcium sensor 1
Sequence	50: MGKSNSKLKP ; EVVEELTRKT ; YFTEKEVQQW ; YKGFIKDCPS ; GQLDAAGFQK ; 100: IYKQFFPFGD ; PTKFATFVFN ; VFDENKDGRI ; EFSEFIQALS ; VTSRGTLDEK ; 150: LRWASKLYDL ; DNDGYITRNE ; MLDIVDAIYQ ; MVGNTVELPE ; EENTPEKRVD ; 190: RIFAMMDKNA ; DGKLTLQEFQ ; EGTKADPSIV ; QALSLYDGLV ;
Sequence Length	190
String	Q2V8Y7
Sub Unit	Interacts in a calcium-independent manner with PI4KB, but only if myristoylated. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with KCND2, ARF1, ARF3, ARF5 and ARF6 (By similarity). Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1.

Uniprot	Q2V8Y7
Gene Name	NCS1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:526544
Unigene	Bt.40187

Reference	1. "Novel Ca2+-modulated frequenin-ROS-GC transduction machinery in bovine hippocampus." Fik-Rymarkiewicz E., Duda T., Sharma R.K. Submitted (2005-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells." Zhao X., Varnai P., Tuymetova G., Balla A., Toth Z.E., Oker-Blom C., Roder J., Jeromin A., Balla T. J. Biol. Chem.276:40183-40189(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PI4KB;SUBCELLULAR LOCATION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808172	E13770b	96T	$900		Add to Cart

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