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ELISA Kit for Bovine NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

SKU : BHE13810094

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0341b
Alternative Names	NAD-dependent ADP-ribosyltransferase sirtuin-4 ; 2.4.2.- ; NAD-dependent protein deacetylase sirtuin-4 ; 3.5.1.- ; Regulatory protein SIR2 homolog 4 ; SIR2-like protein 4
Categories	Elisa
Function	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
Specificity	Natural and recombinant Bovine NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Subcellular Location	Mitochondrion matrix
Entryname	SIR4_BOVIN
Platform	PF02146
Protein Name	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Sequence	50: MRMSFGLTFK ; RTAKVHWRAN ; FSQQCSLRST ; GLFVPPSPPL ; DPEKVKELQR ; 100: FITLSKRLLV ; MTGAGISTES ; GIPDYRSEKV ; GLYARTDRRP ; IQHGDFVRSA ; 150: PVRQRYWARN ; FVGWPQFSSR ; QPNPAHWALS ; NWERLGKLHW ; LVTQNVDALH ; 200: TKAGSQRLTE ; LHGCMHRVLC ; LDCGEQTPRG ; VLQERFQVLN ; PTWSAEAHGL ; 250: APDGDVFLTE ; EEVQSFQVPS ; CSRCGGPLKP ; DVVFFGDTVK ; PDKVDFVHKR ; 300: VKEADSLLVV ; GSSLQVYSGY ; RFILTAREKK ; LPIVILNIGP ; TRSDDLASLK ; 315: LDSRCGELLP ; LIDPR
Sequence Length	315
Sub Unit	Interacts with GLUD1, IDE and SLC25A5.

Uniprot	Q1JQC6
Gene Name	SIRT4
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:519328
Unigene	Bt.39710

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2006-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Ascending colon.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810094	E0341b	96T	$900		Add to Cart

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