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ELISA Kit for Bovine N-lysine methyltransferase SETD8

SKU : BHE13810338

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3859b
Alternative Names	H4-K20-HMTase SETD8 ; Histone-lysine N-methyltransferase SETD8 ; PR/SET domain-containing protein 07 ; PR-Set7 ; PR/SET07 ; SET domain-containing protein 8 ; 2.1.1.43
Categories	Elisa
Function	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
Specificity	Natural and recombinant Bovine N-lysine methyltransferase SETD8
Subcellular Location	Nucleus Chromosome Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Entryname	SETD8_BOVIN
Platform	PF00856
Protein Name	N-lysine methyltransferase SETD8
Sequence	50: MARGRKMSKP ; RAVEAAAAAA ; AVAATAPGPE ; MVERRGPGRP ; RTNGENVFTG ; 100: QSKIYTYMSP ; NKCSGMRSPL ; QEENSVAQYE ; VKCQGKPLAG ; IYRKRDEKRN ; 150: SGNAIRSSMK ; AEEQKIKDAR ; RGPLAPFPNQ ; KSEAAEPPKT ; PTSSCDTPNA ; 200: AAAKQGLKKP ; VRGKQAPRKK ; AQGKTQQNRK ; LTDFYPVRRS ; SRKSKAELQS ; 250: EERKRIDELI ; ESGKEEGMKI ; DLIDGKGRGV ; IATKQFSRGE ; FVVEYHGDLI ; 300: EITDAKKREA ; LYAQDPSTGC ; YMYYFQYLSK ; TYCVDATRET ; NRLGRLINHS ; 350: KCGNCQTKLH ; DIDGVPHLIL ; IASRDIEAGE ; ELLYDYGDRS ; RASIEAYPWL ; 352: KH
Sequence Length	352
String	Q2YDJ8
Sub Unit	Interacts with L3MBTL1.

Uniprot	Q2YDJ8
Gene Name	SETD8
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:532622
Unigene	Bt.65045

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810338	E3859b	96T	$900		Add to Cart

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