ELISA Kit for Bovine Macrophage migration inhibitory factor

Mfr.No.	E0698b
Alternative Names	L-dopachrome isomerase ; L-dopachrome tautomerase ; 5.3.3.12 ; Phenylpyruvate tautomerase ; p12A
Categories	Elisa
Function	Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Specificity	Natural and recombinant Bovine Macrophage migration inhibitory factor
Subcellular Location	Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Entryname	MIF_BOVIN
Method Type	Sandwich
Platform	PF01187
Protein Name	Macrophage migration inhibitory factor
Sequence	50: MPMFVVNTNV ; PRASVPDGLL ; SELTQQLAQA ; TGKPAQYIAV ; HVVPDQLMTF ; 100: GGSSEPCALC ; SLHSIGKIGG ; AQNRSYSKLL ; CGLLTERLRI ; SPDRIYINFC ; 115: DMNAANVGWN ; GSTFA
Sequence Length	115
String	P80177
Sub Unit	Homotrimer. Interacts with BNIPL (By similarity). Interacts with the CD74 extracellular domain. Interacts with COPS5 and with the CXCR2 extracellular domain.

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Ileum. 2. "A diversified family of 12-kDa proteins with a high amino acid sequence similarity to macrophage migration-inhibitory factor (MIF)." Galat A., Riviere S., Bouet F., Menez A. Eur. J. Biochem.224:417-421(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-115 tissue: Brain. 3. "Macrophage migration inhibitory factor in the bovine corpus luteum: characterization of steady-state messenger ribonucleic acid and immunohistochemical localization." Bove S.E., Petroff M.G., Nishibori M., Pate J.L. Biol. Reprod.62:879-885(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-104 tissue: Corpus luteum. 4. "Purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol." Galat A., Riviere S., Bouet F. FEBS Lett.319:233-236(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-40 tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812192	E0698b	96T	$900		Add to Cart