Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.
Specificity
Natural and recombinant Bovine Long-chain fatty acid transport protein 1
Subcellular Location
Cell membrane Single-pass membrane protein Endomembrane system Single-pass membrane protein Cytoplasm Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.
"Bovine solute carrier family 27 member 1 (SLC27A1) gene: structural and functional analysis." Ordovas L., Zaragoza P., Rodellar C. Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
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Reviews of ELISA Kit for Bovine Long-chain fatty acid transport protein 1