This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves after 'Lys-31' APEX1 and destroys its oxidative repair activity. Involved in apoptosis.
Specificity
Natural and recombinant Bovine Granzyme A
Subcellular Location
Secreted Cytoplasmic granule Cytoplasmic granules of cytolytic T-lymphocytes.