Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Specificity
Natural and recombinant Bovine Gamma-secretase subunit PEN-2
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus cis-Golgi network membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.