Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
Specificity
Natural and recombinant Bovine Coxsackievirus and adenovirus receptor homolog
Subcellular Location
Cell junction Cell membrane Single-pass type I membrane protein Cell junction tight junction Basolateral cell membrane Single-pass type I membrane protein Cell junction adherens junction Localized at the intercellular contacts. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
Monomer. Probably homodimer formed by 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with DNAJC7. Probably part of a complex containing CXADR, HSP90AA1 and DNAJC7.