Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.
Specificity
Natural and recombinant Bovine C-C chemokine receptor type 5
Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2.
"Molecular cloning and characterization of bovine chemokine receptors." Blumerman S.L., Baldwin C.L. Submitted (2004-11) to the EMBL/GenBank/DDBJ databases
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