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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Beta-secretase 1

SKU : BHE13801473

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0718b
Alternative Names	Beta-site amyloid precursor protein cleaving enzyme 1 ; Beta-site APP cleaving enzyme 1 ; Memapsin-2 ; Membrane-associated aspartic protease 2
Categories	Elisa
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Specificity	Natural and recombinant Bovine Beta-secretase 1
Subcellular Location	Membrane Single-pass type I membrane protein Golgi apparatus trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Entryname	BACE1_BOVIN
Platform	PF00026
Protein Name	Beta-secretase 1
Sequence	50: MAQALPWLLL ; WMGSGVLPAH ; GSQPGIRLPL ; RSGLGGAPLG ; LRLPRETDEE ; 100: SEEPGRRGSF ; VEMVDNLRGK ; SGQGYYVEMT ; LGSPPQTLNI ; LVDTGSSNFA ; 150: VGAAPHPFLH ; RYYQRQLSST ; YRDLRKGVYV ; PYTQGKWEGE ; LGTDLVSIPH ; 200: GPNVTVRANI ; AAITESDKFF ; INGSNWEGIL ; GLAYAEIARP ; DDSLEPFFDS ; 250: LVKQTHVPNL ; FSLQLCGAGF ; PLNQSEALAS ; VGGSMIIGGI ; DHSLYMGSLW ; 300: YTPIRREWYY ; EVIIVRVEIN ; GQDLKMDCKE ; YNYDKSIVDS ; GTTNLRLPKK ; 350: VFEAAVKSIK ; AASSTEKFPD ; GFWLGEQLVC ; WQAGTTPWNI ; FPVISLYLMG ; 400: EVTNQSFRIT ; ILPQQYLRPV ; EDVATSQDDC ; YKFAISQSST ; GTVMGAVIME ; 450: GFYVVFDRAR ; KRIGFAVSAC ; HVHDEFRTAA ; VEGPFVTPDM ; EDCGYNIPQT ; 500: DESTLMTIAY ; VMAAICALFM ; LPLCLMVCQW ; RCLRCLRHQH ; DDFADDISLL ; 501: K
Sequence Length	501
String	Q2HJ40
Sub Unit	Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6.

Uniprot	Q2HJ40
Gene Name	BACE1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:614333
Unigene	Bt.28273

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2006-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Uterus.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801473	E0718b	96T	$900		Add to Cart

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