Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Specificity
Natural and recombinant Bovine Aryl hydrocarbon receptor nuclear translocator
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with NOCA7 and TACC3.
"Characterization of bovine endothelial aryl hydrocarbon receptor nuclear translocator." Hara S., Takahashi R., Kobayashi C., Imura N. Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
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Reviews of ELISA Kit for Bovine Aryl hydrocarbon receptor nuclear translocator