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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Apoptosis regulator Bcl-2

SKU : BHE13801318

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0778b
Categories	Elisa
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Specificity	Natural and recombinant Bovine Apoptosis regulator Bcl-2
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Detection Range	1.56-100ng/mL
Entryname	BCL2_BOVIN
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator Bcl-2
Sensitivity	0.52ng/mL
Sequence	50: MAHAGGTGYD ; NREIVMKYIH ; YKLSQRGYEW ; DAGDAGAAPP ; GAAPAPGILS ; 100: SQPGRTPAPS ; RTSPPPPPAA ; AAGPAPSPVP ; PVVHLTLRQA ; GDDFSRRYRR ; 150: DFAEMSSQLH ; LTPFTARERF ; ATVVEELFRD ; GVNWGRIVAF ; FEFGGVMCVE ; 200: SVNREMSPLV ; DSIALWMTEY ; LNRHLHTWIQ ; DNGGWDAFVE ; LYGPSMRPLF ; 229: DFSWLSLKAL ; LSLALVGACI ; TLGAYLGHK
Sequence Length	229
String	O02718
Sub Unit	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with FKBP8, APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Interacts with BAG1 in an ATP-dependent manner.

Uniprot	O02718
Gene Name	BCL2
Immunogen Species	Bos Taurus (Cattle)
Unigene	Bt.48090

Reference	1. "Increased ratio of bcl-2/bax expression is associated with bovine leukemia virus-induced leukemogenesis in cattle." Reyes R.A., Cockerell G.L. Virology242:184-192(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Holstein. tissue: Thymus.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801318	E0778b	96T	$900		Add to Cart

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