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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Advanced glycosylation end product-specific receptor

SKU : BHE13808584

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1956b
Alternative Names	Receptor for advanced glycosylation end products ; RAGE
Categories	Elisa
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Specificity	Natural and recombinant Bovine Advanced glycosylation end product-specific receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Entryname	RAGE_BOVIN
Platform	PF08205
Protein Name	Advanced glycosylation end product-specific receptor
Sequence	50: MAAGAVVGAW ; MLVLSLGGTV ; TGDQNITARI ; GKPLVLNCKG ; APKKPPQQLE ; 100: WKLNTGRTEA ; WKVLSPQGDP ; WDSVARVLPN ; GSLLLPAVGI ; QDEGTFRCRA ; 150: TSRSGKETKS ; NYRVRVYQIP ; GKPEIVDPAS ; ELMAGVPNKV ; GTCVSEGGYP ; 200: AGTLNWLLDG ; KTLIPDGKGV ; SVKEETKRHP ; KTGLFTLHSE ; LMVTPARGGA ; 250: LHPTFSCSFT ; PGLPRRRALH ; TAPIQLRVWS ; EHRGGEGPNV ; DAVPLKEVQL ; 300: VVEPEGGAVA ; PGGTVTLTCE ; APAQPPPQIH ; WIKDGRPLPL ; PPGPMLLLPE ; 350: VGPEDQGTYS ; CVATHPSHGP ; QESRAVSVTI ; IETGEEGTTA ; GSVEGPGLET ; 400: LALTLGILGG ; LGTVALLIGV ; IVWHRRRQRK ; GQERKVPENQ ; EEEEEERAEL ; 416: NQPEEPEAAE ; SSTGGP
Sequence Length	416
String	Q28173
Sub Unit	Interacts with S100B, S100A1, S100A12 and APP.

Uniprot	Q28173
Gene Name	AGER
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:280986
Unigene	Bt.103300

Reference	1. "Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins." Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.C., Elliston K., Stern D., Shaw A. J. Biol. Chem.267:14998-15004(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 63-70; 140-159; 162-168; 182-196 AND 228-231 tissue: Lung. 2. "Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface." Schmidt A.M., Vianna M., Gerlach M., Brett J., Ryan J., Kao J., Esposito C., Hegarty H., Hurley W., Clauss M. J. Biol. Chem.267:14987-14997(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-54

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808584	E1956b	96T	$900		Add to Cart

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