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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine 3-hydroxy-3-methylglutaryl-coenzyme A reductase

SKU : BHE13805267

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10451b
Categories	Elisa
Function	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Specificity	Natural and recombinant Bovine 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein
Entryname	HMDH_BOVIN
Method Type	Sandwich
Platform	PF00368
Protein Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Sequence	50: MLSRLFRMHG ; LFVASHPWEV ; IVGTVTLTIC ; MMSMNMFTGN ; NKICGWNYEC ; 100: PKLEEDVLSS ; DIIILTITRC ; IAILYIYFQF ; QNLRQLGSKY ; ILGIAGLFTI ; 150: FSSFVFSTVV ; IHFLDKELTG ; LNEALPFFLL ; LVDLSRASAL ; AKFALSSNSQ ; 200: DEVRENIARG ; MAILGPTFTL ; DALVECLVIG ; VGTMSGVRQL ; EIMCCFGCMS ; 250: VLANYFVFMT ; FFPACVSLVL ; ELSRESREGR ; PIWQLSHFAR ; VLEEEENKPN ; 300: PVTQRVKMIM ; SLGLVLVHAH ; SRWIADPSPQ ; NSTADNSKVS ; LGLDENVSKR ; 350: IEPSVSLWQF ; YLSKMISMDI ; EQVITLSLAL ; LLAVKYIFFE ; QAETESTLSL ; 400: KNPITSPVVT ; QKKITDDCCR ; RDPVLVRNDQ ; KFHAMEEETR ; KNRERKVEVI ; 450: KPLLAENDTS ; HRATFVVGNS ; SLLGTSLELE ; TQEPEMELPV ; EPRPNEECLQ ; 500: ILENAEKGAK ; FLSDAEIIQL ; VNAKHIPAYK ; LETLMETHER ; GVSIRRQLLS ; 550: KKLPEPSSLQ ; YLPYRDYNYS ; LVMGACCENV ; IGYMPIPVGV ; AGPLCLDGKE ; 600: FQVPMATTEG ; CLVASTNRGC ; RAIGLGGGAS ; SRVLADGMTR ; GPVVRFPRAC ; 650: DSAEVKAWLE ; TPEGFTVIKE ; AFDSTSRFAR ; LQKLHMSVAG ; RNLYIRFQSR ; 700: SGDAMGMNMI ; SKGTEKALSK ; LQEYFPEMQI ; LAVSGNYCTD ; KKPAAINWIE ; 750: GRGKSVVCEA ; VIPAKVVREV ; LKTTTEAMIE ; VNINKNLVGS ; AMAGSIGGYN ; 800: AHAANIVTAI ; YIACGQDAAQ ; NVGSSNCITL ; MEASGPTNED ; LYISCTMPSI ; 850: EIGTVGGGTN ; LLPQQACLQM ; LGVQGACRDN ; PGENARQLAR ; IVCGTVMAGE ; 888: LSLMAALAAG ; HLVRSHMIHN ; RSKINLQDLQ ; GTCTKKAA
Sequence Length	888
Sub Unit	Homodimer (By similarity). Interacts with INSIG1 (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.

Uniprot	A7Z064
Gene Name	HMGCR
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:407159
Unigene	Bt.11465

Reference	1. "A whole-genome assembly of the domestic cow, Bos taurus." Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L. Genome Biol.10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Hereford. 2. NIH - Mammalian Gene Collection (MGC) project Submitted (2007-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Hippocampus.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805267	E10451b	96T	$900		Add to Cart

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