Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3.
Specificity
Natural and recombinant Pig Signal transducer and activator of transcription 2
Subcellular Location
Cytoplasm Nucleus Translocated into the nucleus upon activation by IFN-alpha/beta.
Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2. Interacts with ARL2BP.