Constitutive NOS ; cNOS ; EC-NOS ; Endothelial NOS ; eNOS ; NOS type III ; NOSIII ; NOS
Categories
Elisa
Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Specificity
Natural and recombinant Pig Nitric oxide synthase, endothelial
Subcellular Location
Membrane caveola Cytoplasm cytoskeleton Golgi apparatus Cell membrane Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.