ELISA Kit for Mouse Toll/interleukin-1 receptor domain-containing adapter protein

Mfr.No.	E4819m
Antigen	TIRAP
Alternative Names	Adaptor protein Wyatt ; MyD88 adapter-like protein ; Mal
Categories	Elisa
Function	Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF-alpha and interleukin-6.
Specificity	Natural and recombinant Mouse Toll/interleukin-1 receptor domain-containing adapter protein
Subcellular Location	Cytoplasm
Detection Range	31.2-2000pg/mL
Entryname	TIRAP_MOUSE
Method Type	Sandwich
Platform	PF01582
Protein Name	Toll/interleukin-1 receptor domain-containing adapter protein
Sensitivity	15.7pg/mL
Sequence	50: MASSSSVPAS ; STPSKKPRDK ; IADWFRQALL ; KKPKKMPISQ ; ESHLYDGSQT ; 100: ATQDGLSPSS ; CSSPPSHSSP ; ESRSSPSSCS ; SGMSPTSPPT ; HVDSSSSSSG ; 150: RWSKDYDVCV ; CHSEEDLEAA ; QELVSYLEGS ; QASLRCFLQL ; RDAAPGGAIV ; 200: SELCQALSRS ; HCRALLITPG ; FLRDPWCKYQ ; MLQALTEAPA ; SEGCTIPLLS ; 241: GLSRAAYPPE ; LRFMYYVDGR ; GKDGGFYQVK ; EAVIHYLETL ; S
Sequence Length	241
String	Q99JY1
Sub Unit	Interacts with BMX and TBK1 (By similarity). Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR. Does not interact with IRAK1-1, nor TLR9.

Reference	1. "TIRAP: an adapter molecule in the Toll signaling pathway." Horng T., Barton G.M., Medzhitov R. Nat. Immunol.2:835-841(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. 2. "Characterization and structural analysis of TIR domain-containing adaptor protein Wyatt." Kirk P.B., Pereira J.P., Bazan J.F. Submitted (2001-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Mammary gland. 4. "Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt." Troutman T.D., Hu W., Fulenchek S., Yamazaki T., Kurosaki T., Bazan J.F., Pasare C. Proc. Natl. Acad. Sci. U.S.A.109:273-278(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3AP1

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811364	E4819m	96T	$776		Add to Cart