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ELISA Kit for Mouse Serine-protein kinase ATM

SKU : BHE13801421

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Mfr.No.	E1361m
Alternative Names	Ataxia telangiectasia mutated homolog ; A-T mutated homolog
Categories	Elisa
Function	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation.
Specificity	Natural and recombinant Mouse Serine-protein kinase ATM
Subcellular Location	Nucleus Cytoplasmic vesicle Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Detection Range	0.312-20ng/mL
Entryname	ATM_MOUSE
Method Type	Sandwich
Platform	PF02259
Protein Name	Serine-protein kinase ATM
Sensitivity	0.156ng/mL
Sequence	50: MSLALNDLLI ; CCRQLEHDRA ; TERRKEVDKF ; KRLIQDPETV ; QHLDRHSDSK ; 100: QGKYLNWDAV ; FRFLQKYIQK ; EMESLRTAKS ; NVSATTQSSR ; QKKMQEISSL ; 150: VRYFIKCANK ; RAPRLKCQDL ; LNYVMDTVKD ; SSNGLTYGAD ; CSNILLKDIL ; 200: SVRKYWCEVS ; QQQWLELFSL ; YFRLYLKPSQ ; DINRVLVARI ; IHAVTRGCCS ; 250: QTDGLPSKFL ; DLFSKAIQYA ; RQEKSSPGLS ; HILAALNIFL ; KSLAVNFRKR ; 300: VCEAGDEILP ; TLLYIWTQHR ; LNDSLKEVII ; ELIQLQIYIH ; HPQGARAPEE ; 350: GAYESMKWKS ; ILYNLYDLLV ; NEISHIGSRG ; KYSSGSRNIA ; VKENLIDLMA ; 400: DICYQLFDAD ; TRSVEISQSY ; VTQRESTDYS ; VPCKRRKIDV ; GWEVIKDYLQ ; 450: KSQSDFDLVP ; WLQITTRLIS ; KYPSSLPNCE ; LSPLILILYQ ; LLPQQRRGER ; 500: IPYVLRCLKE ; VALCQGKKSN ; LESSQKSDLL ; KLWIKIWSIT ; FRGISSGQTQ ; 550: TENFGLLEAI ; IQGSLVELDR ; EFWKLFTGSA ; CKPSSPSVCC ; LTLALSICVV ; 600: PDAIKMGTEQ ; SVCEANRSFS ; VKESIMRWLL ; FYQLEDDLED ; STELPPILQS ; 650: NFPHLVVEKI ; LVSLTMKNSK ; AAMKFFQSVP ; ECEQHCEDKE ; EPSFSEVEEL ; 700: FLQTTFDKMD ; FLTTVKEYAV ; EKFQSSVGFS ; VQQNLKESLD ; HYLLGLSEQL ; 750: LSNYSSEITS ; SETLVRCSSL ; LVGVLGCYCY ; MGIITEDEAH ; KSELFQKAKS ; 800: LMQCAGESIS ; LFKNKTNEES ; RIGSLRNVMH ; LCTSCLCIHT ; KHTPNKIASG ; 850: FFLRLLTSKL ; MNDIADICKS ; LASCTKKPLD ; HGVHPGEDDE ; DGGGCDSLME ; 900: AEGPSSTGLS ; TAYPASSVSD ; ANDYGENQNA ; VGAMSPLAAD ; YLSKQDHLLL ; 950: DMLRFLGRSV ; TASQSHTVSF ; RGADIRRKLL ; LLLDSSILDL ; MKPLHLHMYL ; 1000: VLLKDLPGNE ; HSLPMEDVVE ; LLQPLSLVCS ; LHRRDQDVCK ; TILSNVLHIV ; 1050: TNLGQGSVDM ; ESTRIAQGHF ; LTVMGAFWHL ; TKEKKCVFSV ; RMALVKCLQT ; 1100: LLEADPYSEW ; AILNVKGQDF ; PVNEAFSQFL ; ADDHHQVRML ; AAGSVNRLFQ ; 1150: DMRQGDFSRS ; LKALPLKFQQ ; TSFNNAYTTA ; EAGIRGLLCD ; SQNPDLLDEI ; 1200: YNRKSVLLMM ; IAVVLHCSPV ; CEKQALFALC ; KSVKENRLEP ; HLVKKVLEKV ; 1250: SESFGCRSLE ; DFMISHLDYL ; VLEWLNLQDT ; EYSLSSFPFM ; LLNYTSIEDF ; 1300: YRSCYKILIP ; HLVIRSHFDE ; VKSIANQIQK ; CWKSLLVDCF ; PKILVHILPY ; 1350: FAYEGTRDSY ; VSQKRETATK ; VYDTLKGEDF ; LGKQIDQVFI ; SNLPEIVVEL ; 1400: LMTLHETADS ; ADSDASQSAT ; ALCDFSGDLD ; PAPNPPYFPS ; HVIQATFAYI ; 1450: SNCHKTKFKS ; ILEILSKIPD ; SYQKILLAIC ; EQAAETNNVF ; KKHRILKIYH ; 1500: LFVSLLLKDI ; QSGLGGAWAF ; VLRDVIYTLI ; HYINKRSSHF ; TDVSLRSFSL ; 1550: CCDLLSRVCH ; TAVTQCKDAL ; ESHLHVIVGT ; LIPLVDYQEV ; QEQVLDLLKY ; 1600: LVIDNKDNKN ; LSVTIKLLDP ; FPDHVIFKDL ; RLTQQKIKYS ; GGPFSLLEEI ; 1650: NHFLSVSAYN ; PLPLTRLEGL ; KDLRRQLEQH ; KDQMLDLLRA ; SQDNPQDGIV ; 1700: VKLVVSLLQL ; SKMAVNQTGE ; REVLEAVGRC ; LGEIGPLDFS ; TIAVQHNKDV ; 1750: SYTKAYGLPE ; DRELQWTLIM ; LTALNNTLVE ; DSVKIRSAAA ; TCLKNILATK ; 1800: IGHIFWENYK ; TSADPMLTYL ; QPFRTSRKKF ; LEVPRSVKED ; VLEGLDAVNL ; 1850: WVPQSESHDI ; WIKTLTCAFL ; DSGGINSEIL ; QLLKPMCEVK ; TDFCQMLLPY ; 1900: LIHDVLLQDT ; HESWRTLLSA ; HVRGFFTSCF ; KHSSQASRSA ; TPANSDSESE ; 1950: NFLRCCLDKK ; SQRTMLAVVD ; YLRRQKRPSS ; GTAFDDAFWL ; DLNYLEVAKV ; 2000: AQSCSAHFTA ; LLYAEIYSDK ; KSTDEQEKRS ; PTFEEGSQGT ; TISSLSEKSK ; 2050: EETGISLQDL ; LLEIYRSIGE ; PDSLYGCGGG ; KMLQPLTRIR ; TYEHEATWEK ; 2100: ALVTYDLETS ; ISSSTRQSGI ; IQALQNLGLS ; HILSVYLKGL ; DYERREWCAE ; 2150: LQELRYQAAW ; RNMQWGLCAS ; AGQEVEGTSY ; HESLYNALQC ; LRNREFSTFY ; 2200: ESLRYASLFR ; VKEVEELSKG ; SLESVYSLYP ; TLSRLQAIGE ; LENSGELFSR ; 2250: SVTDRERSEA ; YWKWQKHSQL ; LKDSDFSFQE ; PLMALRTVIL ; ETLVQKEMER ; 2300: SQGACSKDIL ; TKHLVEFSVL ; ARTFKNTQLP ; ERAIFKIKQY ; NSAICGISEW ; 2350: HLEEAQVFWA ; KKEQSLALSI ; LKQMIKKLDS ; SFKDKENDAG ; LKVIYAECLR ; 2400: VCGSWLAETC ; LENPAVIMQT ; YLEKAVKVAG ; SYDGNSRELR ; NGQMKAFLSL ; 2450: ARFSDTQYQR ; IENYMKSSEF ; ENKQTLLKRA ; KEEVGLLREH ; KIQTNRYTVK ; 2500: VQRELELDEC ; ALRALREDRK ; RFLCKAVENY ; INCLLSGEEH ; DLWVFRLCSL ; 2550: WLENSGVSEV ; NGMMKKDGMK ; ISSYKFLPLM ; YQLAARMGTK ; MTGGLGFHEV ; 2600: LNNLISRISL ; DHPHHTLFII ; LALANANKDE ; FLSKPETTRR ; SRITKSTSKE ; 2650: NSHLDEDRTE ; AATRIIHSIR ; SKRCKMVKDM ; EALCDAYIIL ; ANMDASQWRA ; 2700: QRKGINIPAN ; QPITKLKNLE ; DVVVPTMEIK ; VDPTGEYENL ; VTIKSFKTEF ; 2750: RLAGGLNLPK ; IIDCVGSDGK ; ERRQLVKGRD ; DLRQDAVMQQ ; VFQMCNTLLQ ; 2800: RNTETRKRKL ; TICTYKVVPL ; SQRSGVLEWC ; TGTVPIGEYL ; VNSEDGAHRR ; 2850: YRPNDFSANQ ; CQKKMMEVQK ; KSFEEKYDTF ; MTICQNFEPV ; FRYFCMEKFL ; 2900: DPAVWFEKRL ; AYTRSVATSS ; IVGYILGLGD ; RHVQNILINE ; QSAELVHIDL ; 2950: GVAFEQGKIL ; PTPETVPFRL ; SRDIVDGMGI ; TGVEGVFRRC ; CEKTMEVMRS ; 3000: SQETLLTIVE ; VLLYDPLFDW ; TMNPLKALYL ; QQRPEDESDL ; HSTPNADDQE ; 3050: CKQSLSDTDQ ; SFNKVAERVL ; MRLQEKLKGV ; EEGTVLSVGG ; QVNLLIQQAM ; 3066: DPKNLSRLFP ; GWKAWV
Sequence Length	3066
String	Q62388
Sub Unit	Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds DNA ends, p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. Interacts with EEF1E1; the interaction, induced on DNA damage, upregulates TP53. Interacts with DCLRE1C, MYST1, KAT5, OBFC2B, ATMIN and CEP164 (By similarity). Interacts with AP2B1 AND AP3B2; the interaction occurs in cytoplasmic vesicles. Interacts with TELO2 AND TTI1. Interacts with DDX1.

Uniprot	Q62388
Gene Name	Atm
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11920
Unigene	Mm.5088

Reference	1. "Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene." Pecker I., Avraham K.B., Gilbert D.J., Savitsky K., Rotman G., Harnik R., Fukao T., Schroeck E., Hirotsume S., Tagle D.A., Collins F.S., Wynshaw-Boris A., Ried T., Copeland N.G., Jenkins N.A., Shiloh Y., Ziv Y. Genomics35:39-45(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "Analysis of the ATM protein in wild-type and ataxia telangiectasia cells." Lakin N.D., Weber P., Stankovic T., Rottinghaus S.T., Taylor A.M.R., Jackson S.P. Oncogene13:2707-2716(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION 4. "Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia." Soares H.D., Morgan J.I., McKinnon P.J. Neuroscience86:1045-1054(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE strain: B6C3-F1. 5. "ATM binds to beta-adaptin in cytoplasmic vesicles." Lim D.-S., Kirsch D.G., Canman C.E., Ahn J.-H., Ziv Y., Newman L.S., Darnell R.B., Shiloh Y., Kastan M.B. Proc. Natl. Acad. Sci. U.S.A.95:10146-10151(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2B1 AND AP3B2 6. "ATM phosphorylates histone H2AX in response to DNA double-strand breaks." Burma S., Chen B.P., Murphy M., Kurimasa A., Chen D.J. J. Biol. Chem.276:42462-42467(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF H2AFX 7. "Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo." Daniel J.A., Pellegrini M., Lee J.H., Paull T.T., Feigenbaum L., Nussenzweig A. J. Cell Biol.183:777-783(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-367; SER-1899 AND SER-1987;FUNCTION;MUTAGENESIS OF SER-367; SER-1899 AND SER-1987 8. "RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci." Hewitt S.L., Yin B., Ji Y., Chaumeil J., Marszalek K., Tenthorey J., Salvagiotto G., Steinel N., Ramsey L.B., Ghysdael J., Farrar M.A., Sleckman B.P., Schatz D.G., Busslinger M., Bassing C.H., Skok J.A. Nat. Immunol.10:655-664(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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