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ELISA Kit for Human Ribonucleoside-diphosphate reductase large subunit

SKU : BHE13809692

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0190h
Alternative Names	Ribonucleoside-diphosphate reductase subunit M1 ; Ribonucleotide reductase large subunit ; RR1
Categories	Elisa
Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Specificity	Natural and recombinant Human Ribonucleoside-diphosphate reductase large subunit
Subcellular Location	Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	RIR1_HUMAN
Method Type	Sandwich
Platform	PF03477
Protein Name	Ribonucleoside-diphosphate reductase large subunit
Sensitivity	0.078ng/mL
Sequence	50: MHVIKRDGRQ ; ERVMFDKITS ; RIQKLCYGLN ; MDFVDPAQIT ; MKVIQGLYSG ; 100: VTTVELDTLA ; AETAATLTTK ; HPDYAILAAR ; IAVSNLHKET ; KKVFSDVMED ; 150: LYNYINPHNG ; KHSPMVAKST ; LDIVLANKDR ; LNSAIIYDRD ; FSYNYFGFKT ; 200: LERSYLLKIN ; GKVAERPQHM ; LMRVSVGIHK ; EDIDAAIETY ; NLLSERWFTH ; 250: ASPTLFNAGT ; NRPQLSSCFL ; LSMKDDSIEG ; IYDTLKQCAL ; ISKSAGGIGV ; 300: AVSCIRATGS ; YIAGTNGNSN ; GLVPMLRVYN ; NTARYVDQGG ; NKRPGAFAIY ; 350: LEPWHLDIFE ; FLDLKKNTGK ; EEQRARDLFF ; ALWIPDLFMK ; RVETNQDWSL ; 400: MCPNECPGLD ; EVWGEEFEKL ; YASYEKQGRV ; RKVVKAQQLW ; YAIIESQTET ; 450: GTPYMLYKDS ; CNRKSNQQNL ; GTIKCSNLCT ; EIVEYTSKDE ; VAVCNLASLA ; 500: LNMYVTSEHT ; YDFKKLAEVT ; KVVVRNLNKI ; IDINYYPVPE ; ACLSNKRHRP ; 550: IGIGVQGLAD ; AFILMRYPFE ; SAEAQLLNKQ ; IFETIYYGAL ; EASCDLAKEQ ; 600: GPYETYEGSP ; VSKGILQYDM ; WNVTPTDLWD ; WKVLKEKIAK ; YGIRNSLLIA ; 650: PMPTASTAQI ; LGNNESIEPY ; TSNIYTRRVL ; SGEFQIVNPH ; LLKDLTERGL ; 700: WHEEMKNQII ; ACNGSIQSIP ; EIPDDLKQLY ; KTVWEISQKT ; VLKMAAERGA ; 750: FIDQSQSLNI ; HIAEPNYGKL ; TSMHFYGWKQ ; GLKTGMYYLR ; TRPAANPIQF ; 792: TLNKEKLKDK ; EKVSKEEEEK ; ERNTAAMVCS ; LENRDECLMC ; GS
Sequence Length	792
String	P23921
Sub Unit	Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B.

Uniprot	P23921
Gene Name	RRM1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6240
Unigene	Hs.445705

Reference	1. "Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes." Parker N.J., Begley C.G., Fox R.M. Nucleic Acids Res.19:3741-3741(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Bone marrow. 2. "Sequence analysis of the large and small subunits of human ribonucleotide reductase." Pavloff N., Rivard D., Masson S., Shen S.-H., Mes-Masson A.-M. DNA Seq.2:227-234(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Mammary carcinoma. 3. "A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region." Bepler G., O'Briant K.C., Kim Y.-C., Schreiber G., Pitterle D.M. Genomics55:164-175(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Lymph. 5. "Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene." Parker N.J., Begley C.G., Fox R.M. Genomics19:91-96(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6 tissue: Placenta. 6. "Human ribonucleotide reductase. Activation and inhibition by analogs of ATP." Harrington J.A., Spector T. Biochem. Pharmacol.42:759-763(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION 7. "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." Xue L., Zhou B., Liu X., Qiu W., Jin Z., Yen Y. Cancer Res.63:980-986(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RRM2B 8. "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits." Qiu W., Zhou B., Darwish D., Shao J., Yen Y. Biochem. Biophys. Res. Commun.340:428-434(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION 9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-376;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 10. "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 11. "Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes." Arnaoutov A., Dasso M. Science345:1512-1515(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;MUTAGENESIS OF ASP-57;INTERACTION WITH AHCYL1 12. "Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization." Fairman J.W., Wijerathna S.R., Ahmad M.F., Xu H., Nakano R., Jha S., Prendergast J., Welin R.M., Flodin S., Roos A., Nordlund P., Li Z., Walz T., Dealwis C.G. Nat. Struct. Mol. Biol.18:316-322(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 75-742 IN COMPLEX WITH ALLOSTERIC EFFECTOR ATP AND MAGNESIUM IONS

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