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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Protein arginine N-methyltransferase 1

SKU : BHE13800986

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15261h
Alternative Names	Histone-arginine N-methyltransferase PRMT1 ; Interferon receptor 1-bound protein 4 ; HMT2 ; HRMT1L2 ; IR1B4
Categories	Elisa
Function	Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
Specificity	Natural and recombinant Human Protein arginine N-methyltransferase 1
Subcellular Location	Nucleus Cytoplasm cytosol
Entryname	ANM1_HUMAN
Platform	PF13847
Protein Name	Protein arginine N-methyltransferase 1
Sequence	50: MENFVATLAN ; GMSLQPPLEE ; VSCGQAESSE ; KPNAEDMTSK ; DYYFDSYAHF ; 100: GIHEEMLKDE ; VRTLTYRNSM ; FHNRHLFKDK ; VVLDVGSGTG ; ILCMFAAKAG ; 150: ARKVIGIECS ; SISDYAVKIV ; KANKLDHVVT ; IIKGKVEEVE ; LPVEKVDIII ; 200: SEWMGYCLFY ; ESMLNTVLYA ; RDKWLAPDGL ; IFPDRATLYV ; TAIEDRQYKD ; 250: YKIHWWENVY ; GFDMSCIKDV ; AIKEPLVDVV ; DPKQLVTNAC ; LIKEVDIYTV ; 300: KVEDLTFTSP ; FCLQVKRNDY ; VHALVAYFNI ; EFTRCHKRTG ; FSTSPESPYT ; 350: HWKQTVFYME ; DYLTVKTGEE ; IFGTIGMRPN ; AKNNRDLDFT ; IDLDFKGQLC ; 361: ELSCSTDYRM ; R
Sequence Length	361
String	Q99873
Sub Unit	Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP.

Uniprot	Q99873
Gene Name	PRMT1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3276
Unigene	Hs.20521

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800986	E15261h	96T	$736		Add to Cart

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