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ELISA Kit for Human Cadherin-5

SKU : BHE13801715

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1366h
Alternative Names	7B4 antigen ; Vascular endothelial cadherin ; VE-cadherin ; CD144
Categories	Elisa
Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Specificity	Natural and recombinant Human Cadherin-5
Subcellular Location	Cell junction Cell membrane Single-pass type I membrane protein Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Detection Range	0.156-10ng/mL
Entryname	CADH5_HUMAN
Method Type	Sandwich
Platform	PF00028
Protein Name	Cadherin-5
Sensitivity	0.1ng/mL
Sequence	50: MQRLMMLLAT ; SGACLGLLAV ; AAVAAAGANP ; AQRDTHSLLP ; THRRQKRDWI ; 100: WNQMHIDEEK ; NTSLPHHVGK ; IKSSVSRKNA ; KYLLKGEYVG ; KVFRVDAETG ; 150: DVFAIERLDR ; ENISEYHLTA ; VIVDKDTGEN ; LETPSSFTIK ; VHDVNDNWPV ; 200: FTHRLFNASV ; PESSAVGTSV ; ISVTAVDADD ; PTVGDHASVM ; YQILKGKEYF ; 250: AIDNSGRIIT ; ITKSLDREKQ ; ARYEIVVEAR ; DAQGLRGDSG ; TATVLVTLQD ; 300: INDNFPFFTQ ; TKYTFVVPED ; TRVGTSVGSL ; FVEDPDEPQN ; RMTKYSILRG ; 350: DYQDAFTIET ; NPAHNEGIIK ; PMKPLDYEYI ; QQYSFIVEAT ; DPTIDLRYMS ; 400: PPAGNRAQVI ; INITDVDEPP ; IFQQPFYHFQ ; LKENQKKPLI ; GTVLAMDPDA ; 450: ARHSIGYSIR ; RTSDKGQFFR ; VTKKGDIYNE ; KELDREVYPW ; YNLTVEAKEL ; 500: DSTGTPTGKE ; SIVQVHIEVL ; DENDNAPEFA ; KPYQPKVCEN ; AVHGQLVLQI ; 550: SAIDKDITPR ; NVKFKFILNT ; ENNFTLTDNH ; DNTANITVKY ; GQFDREHTKV ; 600: HFLPVVISDN ; GMPSRTGTST ; LTVAVCKCNE ; QGEFTFCEDM ; AAQVGVSIQA ; 650: VVAILLCILT ; ITVITLLIFL ; RRRLRKQARA ; HGKSVPEIHE ; QLVTYDEEGG ; 700: GEMDTTSYDV ; SVLNSVRRGG ; AKPPRPALDA ; RPSLYAQVQK ; PPRHAPGAHG ; 750: GPGEMAAMIE ; VKKDEADHDG ; DGPPYDTLHI ; YGYEGSESIA ; ESLSSLGTDS ; 784: SDSDVDYDFL ; NDWGPRFKML ; AELYGSDPRE ; ELLY
Sequence Length	784
String	P33151
Sub Unit	Interacts via cadherin 5 domain with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1.

Uniprot	P33151
Gene Name	CDH5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:1003
Unigene	Hs.76206

Reference	1. "Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin." Breviario F., Caveda L., Corada M., Martin-Padura I., Navarro P., Golay J., Introna M., Gulino D., Lampugnani M.G., Dejana E. Arterioscler. Thromb. Vasc. Biol.15:1229-1239(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-517 tissue: Endothelial cell. 2. "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion." Ali J., Liao F., Martens E., Muller W.A. Microcirculation4:267-277(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Placenta. 3. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J.349:159-167(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-517 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-517 5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." Suzuki S., Sano K., Tanihara H. Cell Regul.2:261-270(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-784 (ISOFORM 1) tissue: Brain. 6. "A novel endothelial-specific membrane protein is a marker of cell-cell contacts." Lampugnani M.G., Resnati M., Raiteri M., Pigott R., Pisacane A., Houen G., Ruco L.P., Dejana E. J. Cell Biol.118:1511-1522(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE tissue: Endothelial cell. 7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-442; ASN-523 AND ASN-535 tissue: Plasma. 8. "A strategy for precise and large scale identification of core fucosylated glycoproteins." Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H. Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-61; ASN-112 AND ASN-442 9. "Cell-cell contact formation goves Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction." Graziani A., Poteser M., Heupel W.M., Schleifer H., Krenn M., Drenckhahn D., Romanin C., Baumgartner W., Groschner K. J. Biol. Chem.285:4213-4223(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPC4 10. "CCM1 regulates vascular-lumen organization by inducing endothelial polarity." Lampugnani M.G., Orsenigo F., Rudini N., Maddaluno L., Boulday G., Chapon F., Dejana E. J. Cell Sci.123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KRIT1 11. "Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin." Brasch J., Harrison O.J., Ahlsen G., Caally S.M., Henderson R.M., Honig B., Shapiro L. J. Mol. Biol.408:57-73(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;GLYCOSYLATION AT ASN-61; ASN-112; ASN-157; ASN-362 AND ASN-442

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