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BHE12113014
Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Not a transporter for 1-methyl-4-phenylpyridinium (MPP), procainamide, creatinine, guanidine, p-aminohippurate (PAH) and the anionic cephalosporin cefalozin. MPP-transport activity has been observed in PubMed: 16928787 and PubMed: 17047166 and may contradict results observed in PubMed: 16850272. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Responsible for the secretion of cationic drugs across the brush border membranes.
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