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Home / ELISA Kit

Rat Kallikrein-6 (KLK6) ELISA Kit

SKU : BHE13700938

Kallikrein 6, also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikrein 6 was originally described from the brain as an enzyme involved in degradation of amyloid plaque protein (APP) and hK6 was thought to be a beta secretase.
Kallikrein 6 was shown to be elevated in the sera patients with Alzheimer s disease and Parkinson s disease and in animal models of multiple sclerosis. The neuronal protein alpha-synuclein was shown to be cleaved by hK6, as has APP and hK6 has been implicated in vascular morphogenesis and angiogenesis. MSP has also been shown to rapidly degrade myelin-specific protein, laminin and fibronectin.

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Mfr.No.	KTE100720
Reactivity	Rat
Assay Duration	Multiple steps standard sandwich ELISA assay with a working time of 3-5 hours. It depends on the experience of the operation person.
Assay Type	Sandwich (quantitative)
Description	This Rat Kallikrein-6 (KLK6) ELISA Kit employs a two-site sandwich ELISA to quantitate KLK6.
Alternative Names	KLK6; Bssp; Klk7; MGC9355; NEUROSIN; PRSS18; PRSS9; SP59; ZYME; hK6; kallikrein 6 (neurosin; zyme); protease M; protease; serine; 18; protease; serine; 9
Detection Method	Colorimetric
Kit Components	Rat Kallikrein-6 microplate Rat Kallikrein-6 standard Rat Kallikrein-6 detect antibody Streptavidin-HRP Standard diluent Assay buffer HRP substrate Stop solution Wash buffer Plate covers
Features	Rat Kallikrein-6 (KLK6) ELISA Kit has high sensitivity and excellent specificity for detection of Rat KLK6. No significant cross-reactivity or interference between Rat KLK6 and analogues was observed.
Calibration Range	Please inquire
Limit Of Detection	Please inquire
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Background	Kallikrein 6, also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikrein 6 was originally described from the brain as an enzyme involved in degradation of amyloid plaque protein (APP) and hK6 was thought to be a beta secretase. Kallikrein 6 was shown to be elevated in the sera patients with Alzheimer s disease and Parkinson s disease and in animal models of multiple sclerosis. The neuronal protein alpha-synuclein was shown to be cleaved by hK6, as has APP and hK6 has been implicated in vascular morphogenesis and angiogenesis. MSP has also been shown to rapidly degrade myelin-specific protein, laminin and fibronectin.
Notes	This Rat Kallikrein-6 (KLK6) ELISA Kit employs a two-site sandwich ELISA to quantitate KLK6 in samples. An antibody specific for KLK6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKLK6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KLK6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KLK6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Usage Notes	Do not mix components from different kit lots or use reagents beyond the kit expiration date. Allow all reagents to warm to room temperature for at least 30 minutes before opening. Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. Unused wells must be kept desiccated at 4 °C in the sealed bag provided. Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes. It is recommended that all samples and standards be assayed in duplicate or triplicate.

Applications	ELISA
Applications Notes	This Rat Kallikrein-6 (KLK6) ELISA Kit employs a two-site sandwich ELISA to quantitate KLK6 in samples. An antibody specific for KLK6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKLK6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KLK6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KLK6 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Storage Instructions	The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.
Shipping	Gel pack with blue ice.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13700938	KTE100720	48 T	$339		Add to Cart
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BHE13700938	KTE100720	96 Tx50	$24569		Add to Cart

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