Human Trichoplein Keratin Filament-binding Protein

Mfr.No.

E6318Hu

Alternative Names

Mitochondrial protein with oncostatic activity;Mitostatin;Protein TCHP;TCHP;Trichoplein keratin filament-binding protein;Tumor suppressor protein

Reactivity

Human

Detection Range

15-3000ng/L

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

61072

Kit Components

Components	Quantity
Pre-coated ELISA Plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

7.45ng/L

Background

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed: 15731013, PubMed: 18931701). Is a negative regulator of ciliogenesis (PubMed: 25270598).

Gene ID	84260
UniProt ID	Q9BT92
Antigen	TCHP

Research Area

Others

Protocol

These standard curves of E6318Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
1600ng/L	2.078	2.119	2.081
	2.159
800ng/L	1.38	1.324	1.286
	1.267
400ng/L	0.653	0.693	0.656
	0.734
200ng/L	0.447	0.402	0.365
	0.357
100ng/L	0.138	0.131	0.094
	0.125
0ng/L	0.034	0.037	0
	0.041

Precision

We measured random samples of E6318Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	205	10.16	5
Intra-Assay	2	18	482.5	22.55	4.7
Intra-Assay	3	18	1144.8	47.92	4.2

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12107680	E6318Hu	48T	$320		Add to Cart
BHE12107680	E6318Hu	96T	$458		Add to Cart

Human Trichoplein Keratin Filament-binding Protein - TCHP ELISA Kit

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