Human Transmembrane Protease Serine 4

Mfr.No.

E6311Hu

Alternative Names

CAP2;CAPH2;Channel-activating protease 2;Membrane-type serine protease 2;MT-SP2;TMPRSS3;TMPRSS4;Transmembrane protease serine 4;Transmembrane protease serine 4 catalytic chain);

Reactivity

Human

Detection Range

0.05-20ng/mL

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

48246

Kit Components

Components	Quantity
Pre-coated ELISA plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

0.019ng/mL

Background

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.

Gene ID	56649
UniProt ID	Q9NRS4
Antigen	TMPRSS4

Research Area

Neuroscience; Cell Biology; Cancer

Protocol

These standard curves of E6311Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
12ng/mL	1.856	1.858	1.819
	1.861
6ng/mL	1.124	1.131	1.092
	1.138
3ng/mL	0.599	0.585	0.546
	0.572
1.5ng/mL	0.276	0.254	0.215
	0.233
0.75ng/mL	0.075	0.115	0.075
	0.155
0ng/mL	0.025	0.039	0
	0.053

Precision

We measured random samples of E6311Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	10.45	0.44	4.22
Intra-Assay	2	18	3.96	0.18	4.48
Intra-Assay	3	18	2.6	0.12	4.76

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12107673	E6311Hu	48T	$320		Add to Cart
BHE12107673	E6311Hu	96T	$458		Add to Cart

Human Transmembrane Protease Serine 4 - TMPRSS4 ELISA Kit

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