GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed: 27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed: 11909953).
Contact us to order
Tel
+1 866.986.9598Bioassay Technology Laboratory
view supplier detailsCredit card payments now incur a 3% fee.