BHE13702771
Son of sevenless homolog 1 (SOS1) is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of SOS1 may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in SOS1 are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
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