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Home / ELISA Kit

Human Short transient receptor potential channel 6 (TRPC6) ELISA Kit

SKU : BHE13702351

TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine (noradrenaline) and epinephrine (adrenaline), dopamine, gamma-aminobutyric acid (GABA), and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which results in the reuptake inhibition.

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Mfr.No.	KTE60132
Reactivity	Human
Assay Duration	Multiple steps standard sandwich ELISA assay with a working time of 3-5 hours. It depends on the experience of the operation person.
Assay Type	Sandwich (quantitative)
Description	This Human Short transient receptor potential channel 6 (TRPC6) ELISA Kit employs a two-site sandwich ELISA to quantitate TRPC6.
Alternative Names	TRPC6; FLJ11098; FLJ14863; FSGS2; TRP6;
Detection Method	Colorimetric
Kit Components	Human Short transient receptor potential channel 6 microplate Human Short transient receptor potential channel 6 standard Human Short transient receptor potential channel 6 detect antibody Streptavidin-HRP Standard diluent Assay buffer HRP substrate Stop solution Wash buffer Plate covers
Features	Human Short transient receptor potential channel 6 (TRPC6) ELISA Kit has high sensitivity and excellent specificity for detection of Human TRPC6. No significant cross-reactivity or interference between Human TRPC6 and analogues was observed.
Calibration Range	Please inquire
Limit Of Detection	Please inquire
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Background	TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS). Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine (noradrenaline) and epinephrine (adrenaline), dopamine, gamma-aminobutyric acid (GABA), and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which results in the reuptake inhibition.
Notes	This Human Short transient receptor potential channel 6 (TRPC6) ELISA Kit employs a two-site sandwich ELISA to quantitate TRPC6 in samples. An antibody specific for TRPC6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTRPC6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TRPC6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TRPC6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Usage Notes	Do not mix components from different kit lots or use reagents beyond the kit expiration date. Allow all reagents to warm to room temperature for at least 30 minutes before opening. Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. Unused wells must be kept desiccated at 4 °C in the sealed bag provided. Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes. It is recommended that all samples and standards be assayed in duplicate or triplicate.

Gene ID	7225

Applications	ELISA
Applications Notes	This Human Short transient receptor potential channel 6 (TRPC6) ELISA Kit employs a two-site sandwich ELISA to quantitate TRPC6 in samples. An antibody specific for TRPC6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTRPC6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TRPC6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TRPC6 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Storage Instructions	The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.
Shipping	Gel pack with blue ice.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13702351	KTE60132	48 T	$339		Add to Cart
BHE13702351	KTE60132	96 T	$589		Add to Cart
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BHE13702351	KTE60132	96 Tx50	$24569		Add to Cart

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