Human Protein (Peptidylprolyl Cis - Trans Isomerase) Nima-interacting 1

Mfr.No.

E0656Hu

Alternative Names

DOD;Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Peptidyl-prolyl cis-trans isomerase Pin1;PIN1;PPIase Pin1;Rotamase Pin1;UBL5

Reactivity

Human

Detection Range

0.5-200ng/L

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

18243

Kit Components

Components	Quantity
Pre-coated ELISA plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

0.29ng/L

Background

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders.

Gene ID	5300
UniProt ID	Q13526
Antigen	PIN1

Research Area

Neuroscience; Cell Biology

Protocol

These standard curves of E0656Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
120ng/L	2.218	2.232	2.176
	2.247
60ng/L	1.767	1.732	1.676
	1.696
30ng/L	1.088	1.126	1.07
	1.164
15ng/L	0.728	0.732	0.676
	0.735
7.5ng/L	0.364	0.374	0.318
	0.384
0ng/L	0.045	0.056	0
	0.067

Precision

We measured random samples of E0656Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	35.54	1.43	4.01
Intra-Assay	2	18	7.44	0.42	5.67
Intra-Assay	3	18	32.68	2.13	6.51

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12102338	E0656Hu	48T	$320		Add to Cart
BHE12102338	E0656Hu	96T	$458		Add to Cart

Human Protein (Peptidylprolyl Cis - Trans Isomerase) Nima-interacting 1 - PIN1 ELISA Kit

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