PDGFRL is a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
The 375-amino acid protein predicted from this cDNA has hydrophobic sequence at the NH2 terminus, characteristic of signal peptides. It shows 27% and 25% identity with the extracellular domain of platelet-derived growth factor receptor-beta and FMS-like tyrosine kinase (FLT), respectively.
Contact us to order
Tel
+1 866.986.9598Abbkine Scientific Co., Ltd.
view supplier detailsCredit card payments now incur a 3% fee.