MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include Herpes Simplex and Pigmented Basal Cell Carcinoma. Among its related pathways are Chromatin organization and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is...
MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include Herpes Simplex and Pigmented Basal Cell Carcinoma. Among its related pathways are Chromatin organization and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA Binds to RNA homopolymer poly(G) and poly(U).
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