Human Interleukin-31 Receptor Subunit Alpha

Mfr.No.

E5522Hu

Alternative Names

Cytokine receptor-like 3;GLM-R;Gp130-like monocyte receptor;Gp130-like receptor;hGLM-R;IL 31;IL-31 receptor subunit alpha;IL-31R subunit alpha;IL31RA;IL-31RA;IL-31R-alpha;Interleukin-31 receptor subunit alpha;ZcytoR17;

Reactivity

Human

Detection Range

3-900ng/L

Sample Type

Serum, Cell culture supernatants, Plasma

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

82954

Kit Components

Components	Quantity
Pre-coated ELISA Plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

1.34ng/L

Background

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed: 11877449, PubMed: 14504285, PubMed: 15627637, PubMed: 15194700). May function in skin immunity (PubMed: 15184896). Mediates IL31-induced itch, probably in a manner dependent on cation Channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Gene ID	133396
UniProt ID	Q8NI17
Antigen	IL31RA

Research Area

Immunology

Protocol

These standard curves of E5522Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
480ng/L	2.323	2.341	2.311
	2.36
240ng/L	1.213	1.262	1.232
	1.312
120ng/L	0.726	0.729	0.698
	0.732
60ng/L	0.446	0.478	0.448
	0.51
30ng/L	0.26	0.234	0.203
	0.208
0ng/L	0.036	0.031	0
	0.025

Precision

We measured random samples of E5522Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	279.1	7.54	2.7
Intra-Assay	2	18	58.2	4.12	7.1
Intra-Assay	3	18	157.4	9.66	6.1

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12106884	E5522Hu	48T	$320		Add to Cart
BHE12106884	E5522Hu	96T	$458		Add to Cart

Human Interleukin-31 Receptor Subunit Alpha - IL31RA ELISA Kit

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