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Plays a role as a transcription factor (PubMed: 22132193, PubMed: 25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed: 25355627, PubMed: 25816751). Mediates negative transcriptional regulation of CDC25B [removed]PubMed: 22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed: 25816751, PubMed: 26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed: 22132193, PubMed: 25355627, PubMed: 26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed: 19238419, PubMed: 22132193). Associates with chromatin to the CDC25B promoter (PubMed: 22132193).
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