MULK contains an N-terminal diacylglycerol (DG) kinase domain, a putative nuclear localization signal, and a region with 44% homology to SPHK2. Comparison of putative vertebrate MULK orthologs showed strong conservation of amino acid sequences, and phylogenetic analysis of lipid kinases demonstrated that human and mouse Mulk together form a distinct lipid kinase family.
Expression of a MULK-EGFP fusion protein in 293T cells and CHO cells showed that MULK fractionates with membranes and localizes to internal membrane compartments. RT-PCR analysis showed MULK is ubiquitously expressed, with highest expression in pancreas and brain.
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