ADAMTS7 is a member of the ADAM protein family . The gene is expressed in human brain, heart, lung, liver, pancreas, kidney, skeletal muscle, and placenta. The murine protein is expressed at low levels throughout mouse development.
The predicted 997-amino acid ADAMTS7 protein has a domain structure characteristic of ADAMTSs.
The mature ADAMTS7 protein has 2 potential N-linked glycosylation sites. Northern blot analysis detected a 5-kb ADAMTS7 transcript in all human tissues examined, namely brain, heart, lung, liver, pancreas, kidney, skeletal muscle, and placenta; skeletal muscle expressed an additional 7-kb transcript. Mouse Adamts7 was expressed at low levels throughout mouse development.
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